Hemodynamic Alterations in Venous Blood Flow Produced by External Pneumatic Compression; Herbert Janssen, PhD, ;Journal of Cardiovascular Surgery, Vol. 34- No. 5; 441- 447.
A Comparison of Compression Pumps in the Treatment of Lymphedema by John J. Bergan, MD, Stephen Sparks, MD, and Niren Angle, MD; Vascular Surgery – Volume 32, Number 5, 455-462.
Dose response of compression therapy for chronic venous edema—high pressures are associated with greater volume reduction: Two randomized clinical studies; Wolfgang Vanscheidt, MD; Alexandra Ukat, MD, Hugo Partsch, MD; presented at the American Venous Forum, February, 20-23, 2008
Importance and Advantages of Intermittent External Pneumatic Compression Therapy in Venous Stasis Ulceration; Ufuk Alpagut, MD and Enver Dayioglu, MD; Angiology – Volume 56: 19-23, 2005
Evaluation of two different intermittent pneumatic compression cycle settings in the healing of venous ulcers: A randomized trial, Nikolovska, Arsovski, Damevska, Gocev, Pavlova; Medical Science Monitor, 2005, vol. 11, n 7, pp. CR337-CR343
Results of an Observational Longitudinal Retrospective Study; Eric J. Lullove DPM and Oscar M. Alvarez PhD, Centers for Curative and Palliative Wound Care, Calvary Hospital, Bronx, NY. Department of Medicine, New York Medical College, Valhalla, NY and West Boca Medical Center, Boca Raton, FL
Effectiveness of Intermittent Pneumatic Compression for the Treatment of Venous Ulcers in Subjects with Secondary Lymphedema by Oscar M. Alvarez PhD1, Martin Wendelken DPM, RN, Lee Markowitz DPM, Rachelle Parker MD, and Christopher Comfort MD; Center for Curative and Palliative Wound Care, Calvary Hospital, Bronx, NY., Department of Medicine, New York Medical College, Valhalla, NY
Tissue Fluid Pressure and Flow during Pneumatic Compression in Lymphedema of Lower Limbs by Waldemar L Olszewski, M.D., Ph.D., Pradeep Jain, M.D., Ph.D., Govinda Ambujam, M.D., Ph.D., Marzanna Zaleska, M.B., Marta Cakala, M.B., and Tomasz Gradalski, M.D., Ph.D. ; LYMPHATIC RESEARCH AND BIOLOGY Volume 9, Number 2, 2011 DOI: 10.1089/lrb.2009.0025
MLD OR PNEUMATIC COMPRESSION? THE EVIDENCE BEHIND THE ACTUAL SCIENCE, Waldemar L Olszewski, M.D., Ph.D., Surgical Research and Transplantation, Medical Research Center, Warsaw, Poland.
Decongestive Lymphatic Therapy for Patients with Breast Carcinoma-Associated Lymphedema, A Randomized, Prospective Study of a Role for Adjunctive Intermittent Pneumatic Compression; Andrzel Szuba, MD, PH D, Radha Achalu, MD, Stanley G. Rockson, MD; Stanford Center for Lymphatic and Venous Disorders, Stanford, CA.
Anatomical distribution of tissue fluid and lymph in soft tissues of lower limbs in obstructive lymphedema, – hints for physiotherapy , Waldemar Olszews, MD, Pradeep Jain, MD, Govinda Ambujam, MD, Marzanna Zaleska, MD, Marta Cakala, MD; Phlebolymphology, 2009; 16 (3): 283-289.
Long-term results of compression treatment for lymphedema Christos J. Pappas, MD, and Thomas F. O’Donnell, Jr., MD, FACS, Boston, Mass. J Vascular Surg 1992; 16: 555-564.
Published research validates the efficacy of VeinOPlus® neuromuscular electro-stimulation (NMES) device in activating the calf muscle pump of the lower extremities in increasing venous outflow and arterial inflow. The studies conclude that the VeinOPlus technology increases venous blood volume/velocity and arterial inflow with resting lower limbs without causing pain in patients having venous and/or arterial insufficiency.
1. Zuccarelli, Launay, MD, LeMagrex Mollard, MD, Fargier, MD, and Pujo, MD. “Activation of the Calf Muscle Pump by VEINOPLUS” Angeiologie 2005; 57:48-54.
2. LeTohic A. et al., Effect of electro-stimulation (VEINOPLUS) on lower limbs during pregnancy. Gynecol Obstet & Fertil 2009; 37:18-24.
3. Griffin, Nicolaides, et al, The efficacy of a new stimulation technology (VeinOPlus) to increase venous flow and prevent venous stasis. Endovasc Surg. 2010 Dec; 40:766-71.
4. Soriano, Moll, Deal. Efficacy and optimal use of a portable electrical muscle stimulator improves symptoms of PTS. Presented at Thrombosis Research Society 2010
5. Bogachev VY, Golovanova OV, Kuznetsov AN. Electromuscular stimulation with VEINOPLUS® for the treatment of chronic venous edema. Int. Angiol. 2011 Dec; 30(6):567-90
6. Abraham P, Mateus V, Bieuzen F et al. Calf muscle stimulation with the VEINOPLUS device results in a significant increase in lower limb inflow without generating limb ischemia or pain in patients with peripheral artery disease. J Vascular Surg. 2013 Mar; 57(3):714-9.
7. Bogachev VY, Lobanov VN, Golovanova OV, Kuznetsov AN. Electrical muscle stimulation with VeinOPlus device in the treatment of venous ulcers. Int. Angiol. 2015; 34:257- 62.
Published research validates the efficacy of VeinOPlus® DVT device (neuromuscular electro-stimulation) in treating calf muscle pump dysfunction in all hospitalized patients including post-surgical and ICU from developing DVT due to being immobilized. Increased venous volume and velocity in the lower extremities helps prevent venous stasis and deep vein thrombosis.
These studies conclude that the VeinOPlus DVT technology increases blood volume and velocity within resting lower limbs without causing pain during extended hours of DVT prophylaxis and compares the technology to walking, nature’s own mechanism for preventing deep vein thrombosis. In addition, VeinOPlus DVT therapy reduces swelling, increases arterial inflow, accelerates healing, and reduces hospital length of stay.
1. Lobastov, Barinov, et al, Electrical calf muscle stimulation with VeinOPlus device in postoperative venous thromboembolism prevention. Int. Angiology 2014
2. Obolenskiy, Karpenko. Efficacy of electrical muscle stimulation in the treatment of patients with shin bone fractures. Wound Medicine 2014.